But Help Is on the Way - Dr. Kathleen T. Ruddy's Breast Cancer Blog

Siege,?Webster?s?definition: ?the act or process of surrounding and attacking a fortified place in such a way as to isolate it from help and supplies for the purpose of lessening the resistance of the defenders and thereby making capture possible.

There?s not a more apt description of metastasis to be found in any textbook of medicine. ?A state of siege is so apropos of what the breast cancer patient faces; but reinforcements for the defense may be on their way!

BACKGROUND: Breast cancer may erupt in errant cells in the breast, quite possibly due to (in many cases) a virus. ? However, the real threat imposed by this malignancy does not issue from the tumor that grows in the breast, but from the terrorist colonies it seeds elsewhere in the body ? that is, metastasis.

Good news: ?a woman from Australia heads the calvary on its way to help

Dr. Belinda Parker of Melbourne compared the genetic profile of cancer cells taken from the primary tumor, located in the breast, and cancer cells taken from metastasis seeded into the bone from those primary tumors. ?She wanted to compare these two groups of cancer cells to see if she could identify any genetic changes that might provide clues as to how and why those primary tumor cells were able to escape the immune system and set up shop in bone.

BACKGROUND: ?Scientists have known for?decades?that primary tumors and their metastatic offspring differ in many respects. ?Often, metastatic cells appear more primitive, behave more aggressively, and are typically more difficult to kill. ?Too, their receptors tend to change: ?what may have begun in the breast as slow-growing, Grade I, estrogen-positive tumors can easily morph into fast-growing, Grade III, estrogen-negative metastasis.

You see, cancer cells never stop tryng to adapt. ?It?s their mission to live forever, stay ahead of the game, and keep well in front of the soldiers sent to fight them ? surgeons, medical oncologists, radiation oncologists, and the like.

OK, back to our good woman in Australia, Dr. Parker.

So, when she examined the two sets of cancer cells, those from primary tumors and those from tumors metastatic to bone, she found one gene in particular,?Irf-7, that had been eliminated from primary tumor cells compared to those metastatic to bone.

Hmmm. ?What does?Irf-7?do?

Well, that?s the gene that regulates interferon.

Oh, yeah. ?Remind me again, what does interferon do?

Yeah, it allows the body to recognize foreign invaders ? evil cells that want to penetrate your fortress. ?Actually, interferon is made by specific white blood cells in the body ? think of them as your ?National Guard?. ?Typically, interferon is used to ferret out viruses. Hmmm, that?s interesting if it?s true that 40-70% of breast cancer is caused by a virus? but back to Parker ?

So, Parker discovered that breast cancer cells that had set up shop in bone were able to escape immune surveillance because they had eliminated?Irf-7.

Then Parker tried to repair the damage.

She took the metastatic breast cancer cells that she?d isolated from the bone of women with metastatic breast cancer ?. you see, she moved from her discovery in mice right to the bedside where she could do the most good ?. and she inserted the missing?Irf-7?gene back inside the cells.

Guess what? ?Once?Irf-7?was put back into the metastatic cancer cells, the immune system started wiping them out again.

Parker examined metastatic breast cells taken from?800?patients: ?her experiments with replacing the missing?Irf-7?prolonged survival and decreased the likelihood of bone metastasis.

Parker was also able to achieve similar results just by exposing the metastatic cells to interferon; thus administering Interferon is a therapeutic alternative worth testing.

Thank you, Dr. Parker.

Reference: ?B. Parker, 2012, Nature Medicine, ?Silencing of Irf-7??

Source: http://breastcancerbydrruddy.com/?p=4010

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Mountain Biking Is The Best Form of Recreation | The Day Times

Mntain biking is a recreational hobby wherein riders ride bicycles off-road on rough terrains. The bicycles used for these game is exclusively manufactured to suit these kind of terrains which are generally tough and patchy. Such bikes are commonly regarded as mountain bikes. These mntain bikes are especially suitable for these kinds of environments. These sorts of bikes look very similar to any other bike, but they are fitted with special features to improve and improve the ride, consolation and most importantly performance on such terrains.

Terrain biking are of different categories such as cross-breed country, dirt jumping and trails to name a few. The most common forms of mountain biking is the recreational and trail using categories. One can perform mntain biking anywhere like on country back roads, off-road trails, zigzag rds thtough forests, on hills or mountains, flds and on paths. because mntain biking involves journeyling on your own and most of the time being away from the civilization, the rider needs to be self-reliant in the hobby. The rider is required to carry a backpack and be equipped with essential items like water, instruments needed for repairs, a first aid kit, and some crisis food packets in case of need arising from any unfortunate incident like injuries. mntain biking thtough clubs or in groups is very common on long treks. This sport has received in commonity after the year 1990 and is acknowledged as a form of recreational sports activity.

Some of the equipments one needs for mtn biking are, a good bike specifically made for performance on terrains which are tough. They have particular exclusive features like dual suspension, broader tires, and flat and raised will need for consolationable riding posture giving good control for the rider. These make of bikes come fitted with disc brakes and gears to assist in climbing hills which are steep and travel through bumpy surfaces. Due to these special capabilities such bikes are heavier as compared to the regular tour bicycles. A rider also needs to carry specific accessories like helmets, gloves, first aid kit, GPS device, pumps to fill flat tires, a good shoe, equipment for the bike etc.

mongrel country is the most preferred form of off-road biking all over the world. This involves travelling from one point to another involving some climbs and descents on different forms of terrains. Trails involve jumping the bikes over obstacles without the rider?s foot touching the land. It is generally performed off-road and demands good balance from the rider. just about every sport has its risks and mntain biking also involves some risks. Without the use of any protective gears a rider can be susceptible to minor as well as some severe accidents to head or spine especifically in downhill biking. With a protective gear one can avoid such severe accidents.

Australia has some excellent terrain biking tours which are eco certified, these tours come with instructions for every kind of biking practical experience be it the rainforest tours or the coastal tours on bikes. They cater to all kinds of rider amateur as well as experienced. practical experience the adventures involved in mtn biking like any other game and also enjoy dynamics at its best. Such form of biking is a great stress buster.

If you?re not terrified of the truth, then you will be ok ? Go Mountain Cycling . If you want to succeed, no matter what? then it?s easy ? Mountain Bikes.

Source: http://thedaytimes.com/2012/07/mountain-biking-is-the-best-form-of-recreation/

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Tech Stocks to Invest in For the Next 10 Years :: The Market Oracle ...

Companies / Tech Stocks Jul 27, 2012 - 10:46 AM

By: Money_Morning

G.S. Early writes: During the great Dotcom days, analysts were fond of saying that "growth is the new income." Back then, tech stocks were all the rage.

Some even went as far to say that if a tech stock didn't have a triple digit price/earnings ratio, it wasn't worth buying. There were even 70 year-olds at the time who bragged about the optical networking stocks they owned - but couldn't program the clock on their VCRs.

That didn't end so well....did it?

But it's been a long time since the Dotcom crash. Twelve years later, tech stocks are stronger than ever.

The trick is to find good companies with good ideas that can translate their core competencies into niches that complement each other.

That way, when one niche falters, the others pick up the slack.

Alternatively, winning tech stocks need to dominate their sector with quality goods, innovative leadership and a dynamic corporate structure. They also have to have proprietary technologies that can keep pace with a rapidly changing marketplace.

If you rest on your laurels these days, it can mean ruination, no matter what size company you are or how much market share you own.

If you doubt that, consider this....

Just five years ago, Research in Motion's (Nasdaq: RIMM) Blackberry was the pinnacle of smartphone technology; now it's listing heavily and may eventually sink. And at one point, Nokia (NYSE: NOK) was the largest mobile phone maker in the world. Now it's become an also-ran. The list goes on and on.

Innovation Is Essential for Tech Stocks
These days, I'm a firm believer in what I call Innovation Investing. In the 21st century, I think this approach is essential.

Investors need to find innovators (big and small) that can build a unique product and know how to get it to market and manage the business.

The future becomes the present very quickly these days and flexible, forward-looking companies that can get the technologies from "lab to fab" (i.e., from the research stage into the product pipeline) quickly will become the ones to thrive in the years to come.

I was talking about this concept a few years back with an executive of a small nanotech firm and he agreed wholeheartedly.

He later confessed he was the former head of research and development at Motorola in early to mid-'90s and his department would invent incredible stuff. The problem was they couldn't get it into production quickly enough.

It's why my two favorites featured below are large tech firms that have the reach and the vision to take advantage of the incredibly fast-paced business environment.

And while I give kudos to Apple Inc. (Nasdaq: AAPL) for moving personal computing as far as it has, the odds are slim that it will lead us into the next generation.

Don't get me wrong, it's a great company with great products. But you can't believe Apple has the only visionaries in the consumer tech space. What's more, given how far they come you have to wonder how much more they can really grow.

Tech Stocks Beyond Cupertino
On the topic of consumer tech, one of my top tech stock picks is Qualcomm Inc. (Nasdaq: QCOM). It is the leading provider of mobile chipsets in the world - and it's a U.S. company.

The thing about QCOM that sets it apart from, say AAPL, is that its chipsets can be found in all mobile phones, tablets, smart grids, modems, 3G/4G networking equipment and..., well you get the point. QCOM works with virtually every phone and device maker.

What's more, QCOM's growth is just beginning since commercial and consumer users increasingly rely on mobile computing and communications.

And while AAPL would have to come up with the new cool device, QCOM just needs to stick to innovating on the chip side so it can continue sell across the entire marketplace.

And talk about innovation. The company just signed a deal with French carmaker Renault to jointly develop wireless charging technologies for electric vehicles.

The company's 3Q revenue was up 28% year-over-year; device sales were up 31%; and operating income was up 24%.

While these numbers are strong given the state of the general economy, the thing to bear in mind is, quarter-to-quarter the stock can have hiccups.

But long term, and that's what we're talking about here, the stock looks extremely promising. Even in the face of a global meltdown, the stock up over 32% over the last five years.

The stock also kicks off a 1.7% dividend as well.

Making Everything Better
My other favorite long-term tech stock is BASF (BASFY). I like to think of this company as the DuPont of the 21st century.

DuPont spent much of the 20th century building upon pioneering chemistry and developing a global reputation for innovation that became so ingrained in everyone's lives that its influence was hardly assumed more than noticed.

To steal a line from one my colleagues, Dr. Tim Harper of Cientifica, nanotechnology is to the 21st century what chemistry was to the 20th century. And without fanfare or marketing hype, BASF has incorporated this technology into every aspect of its business.

The company is actually one of the world's leading patent holders in nanotechnologies. And it gives BASF's entire product portfolio an edge in staying on the vanguard.

Nanotechnologies allow researchers to manipulate materials down to the molecular and even atomic level. That means scientists can custom build substances to enhance the way they work in materials or other substances.

It means you can build a water-based paint with no toxic fumes that is as durable as an oil-based paint. Or building "smart" insulating properties into housing materials that keep the house warmer in the winter and cooler in the summer. And that is just the beginning.

Plus, it kicks off a nice 4.9% dividend. In my mind, that makes BASF buy below $73 as a great long-term growth stock posing as a great total return play.

Source :http://moneymorning.com/2012/07/27/2-tech-stocks-for-the-next-10-years-and-neither-one-is-apple/

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Source: http://www.marketoracle.co.uk/Article35798.html

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Steam store reveals a handful of new categories, hints at non-gaming app possibilities

Steam's Android app has thrown up a selection of new categories that point to the possibility of productivity apps and other types of non-gaming software being sold in the near-future. Ranging from photo editing to accounting, there's ten categories that aren't available on the desktop version. It would open up yet another branch for Valve, which already offers books and movies through its online store, but until these categories get fleshed-out -- they're currently empty -- we're left guessing as to what it's likely to offer.

Filed under: Internet, Software

Steam store reveals a handful of new categories, hints at non-gaming app possibilities originally appeared on Engadget on Mon, 16 Jul 2012 07:56:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Nk45P-qcYBU/

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Feline mayor is the cat's pajamas in Alaska town

TALKEETNA, Alaska (AP) ? The mayor of a sleepy Alaska town is feline fine.

• 

  By Sandy Bubar, AP

  Stubbs lies on a tarp in an alley in Talkeetna, Alaska, on Wednesday.

By Sandy Bubar, AP

Stubbs lies on a tarp in an alley in Talkeetna, Alaska, on Wednesday.

The part-Manx cat clawed his way onto the political scene of Talkeetna, Alaska, through a write-in campaign shortly after he was born 15 years ago.

KTUU-TV reported Friday that residents didn't like the mayoral candidates years ago, so they encouraged enough people to elect Stubbs as a write-in candidate. The town has nearly 900 residents.

Although his position is honorary, Stubbs' popularity is real. His election earned him enough press to catapult the town at the base of Mount McKinley into a tourist destination.

Residents say they're happy that their stubby-tailed mayor is promoting tourism. The general store where Stubbs hangs out says it gets dozens of tourists a day asking for him.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

For more information about reprints & permissions, visit our FAQ's. To report corrections and clarifications, contact Standards Editor Brent Jones. For publication consideration in the newspaper, send comments to letters@usatoday.com. Include name, phone number, city and state for verification. To view our corrections, go to corrections.usatoday.com. USA TODAY is now using Facebook Comments on our stories and blog posts to provide an enhanced user experience. To post a comment, log into Facebook and then "Add" your comment. To report spam or abuse, click the "X" in the upper right corner of the comment box. To find out more, read the FAQ and Conversation Guidelines.?

Source: http://rssfeeds.usatoday.com/~r/UsatodaycomNation-TopStories/~3/3oD9Uhx05t0/1

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Baseball great pleads guilty to bankruptcy fraud

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Source: http://news.yahoo.com/baseball-great-pleads-guilty-bankruptcy-fraud-213554660--mlb.html

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Clinton Talks with Egyptian Leaders (Voice Of America)

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