Star Trek Into Darkness Clip: Kirk and Harrison

Source: http://www.thehollywoodgossip.com/2013/04/star-trek-into-darkness-clip-kirk-and-harrison/

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Collapsed building owner arrested on India border

SAVAR, Bangladesh (AP) ? The owner of an illegally-constructed building that collapsed last week in a deadly heap in a Dhaka suburb was arrested at a border crossing with India on Sunday in a dramatic operation by members of an elite commando force, a government minister said.

A fleeing Mohammed Sohel Rana was arrested near the land-crossing in Benapole in western Bangladesh, just as he was about to cross into India's West Bengal state, said Jahangir Kabir Nanak, junior minister for local government. He said Rana is being brought back by helicopter to the capital Dhaka where he faces charges of negligence.

The arrest by the Rapid Action Battalion was announced on a loudspeaker at the site of the collapsed building in a Dhaka suburb, where people greeted it with cheers and claps. At least 362 people are confirmed to have died in the collapse of the 8-story building on Wednesday. Three of its floors were built illegally.

The death toll is expected to rise but it is already the deadliest tragedy to hit Bangladesh's garment industry, which is worth $20 billion annually and a mainstay of the economy. The collapse and previous disasters in garment factories have focused attention on the poor working conditions of workers who toil for as little as $38 a month to produce clothing for top international brands.

Rana, a small-time politician from the ruling party, had been on the run since Wednesday. He last appeared in public in front of Rana Plaza on Tuesday after huge cracks appeared in the structure. However, he assured tenants, including five garment factories, that the building was safe.

A bank and some shops on the first floor shut their premises on Wednesday after police ordered an evacuation, but managers of the garment factories on the upper floor told workers to continue their shifts.

Hours later Rana Plaza was reduced to rubble, and most victims were crushed by massive blocks of concrete and mortar falling on them. A garment manufacturers' group said the factories in the building employed 3,122 workers, but it was not clear how many were inside it when it collapsed. About 2,500 survivors have been accounted for.

On Sunday, rescuers located nine people alive inside the rubble on Sunday, as authorities announced they will now use heavy equipment to drill a central hole from the top to look for survivors and dead bodies.

Army Maj. Gen. Chowdhury Hasan Suhrawardy, the coordinator of the rescue operations, said they will try to save the nine people first by manually shifting concrete blocks with the help of light equipment such as pick axes and shovels.

"But if we fail we will start our next phase within hours," which would involve manual efforts as well as heavy equipment, including hydraulic cranes and cutters to bore a hole from the top of the collapsed building, he told reporters.

The purpose is to "continue the operation to recover both survivors and dead bodies. In this stage, we have no other choice but to use some heavy equipment. We will start it within a few hours. Manual operation and use of small equipment is not enough," he said.

The work will be carried out carefully so as not to mutilate bodies, he said. All the equipment is in place, "from a small blade to everything. We have engaged many private sector companies which supplied us equipment, even some heavy ones."

In rare good news, a female worker was pulled out alive on Sunday. Hasan Akbari, a rescuer, said when he tried to extricate a man next to the woman, "he said his body was being torn apart. So I had to let go. But God willing, we will be able to rescue him with more help very soon."

On Saturday, police took six people into custody, including three owners of two factories who were placed under arrest. Also under detention are Rana's wife and two government engineers who were involved in giving approval for the building design.

Local television stations reported that the Bangladesh High Court has frozen the bank accounts of the owners of all five garment factories in the collapsed building.

Working round-the-clock, rescuers have used bare hands and shovels, passing chunks of brick and concrete down a human chain away from the collapsed structure. On the ground, mixed in the debris were several pairs of pink cotton pants, a mud-covered navy blue sock and a pile of green uncut fabric.

The badly decomposed bodies pulled out of the rubble were kept at a makeshift morgue at the nearby Adharchandra High School before being handed over to families. Many people milled around at the school, waving photos of their missing loved ones.

Rana was a local leader of ruling Awami League's youth front. His arrest, and that of the factory owners, was ordered by Prime Minister Sheikh Hasina, who is also the Awami League leader.

The disaster is the worst ever for the country's booming and powerful garment industry, surpassing a fire five months ago that killed 112 people and brought widespread pledges to improve worker-safety standards. But since then very little has changed in Bangladesh, where low wages have made it a magnet for numerous global brands.

Bangladesh's garment industry was the third largest in the world in 2011, after China and Italy, having grown rapidly in the past decade. The country's minimum wage is the equivalent of about $38 a month.

Among the garment makers in the building were Phantom Apparels, Phantom Tac, Ether Tex, New Wave Style and New Wave Bottoms. Altogether, they produced several million shirts, pants and other garments a year.

The New Wave companies, according to their website, make clothing for several major North American and European retailers.

Britain's Primark acknowledged it was using a factory in Rana Plaza, but many other retailers distanced themselves from the disaster, saying they were not involved with the factories at the time of the collapse or had not recently ordered garments from them.

Wal-Mart said none of its clothing had been authorized to be made in the facility, but it is investigating whether there was any unauthorized production.

__

AP writers Farid Hossain and Gillian Wong in Dhaka contributed to this report.

Source: http://news.yahoo.com/collapsed-building-owner-arrested-india-border-092723478.html

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How would you change Sony's VAIO T13?

Sony's VAIO T13 was a sub-$1000 Ultrabook with an eye on the education market. While we were impressed by the results, its low price meant that compromises had to be made -- especially in the keyboard department. In fact, we were saddened to see that it was packing shallow keys and weirdly wide spacing that made it uncomfortable to type on. But if you were one of those back-to-schoolers who bought one, what did you think of it and what would you have changed about it?

Filed under: Laptops, Sony

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/rSVB4ZwPInc/

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Amanda Bynes Shaves Half Her Head

Source: http://www.thehollywoodgossip.com/2013/04/amanda-bynes-shaves-half-her-head/

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PFT: Packers announce extension with Rodgers

Reuters

For months, it was assumed the Chiefs would take tackle Luke Joeckel with the first pick in the draft.? Last night, the reality become otherwise.

The Chiefs bypassed Joeckel for Eric Fisher, and Joeckel won?t forget it.

?I wanted that first pick but, you know, it didn?t happen. And that definitely puts a chip on my shoulder,? Joeckel told PFT on Thursday night, after he was picked.? ?I?m ready to go work, I?m ready to go prove myself.? It kind of hurts even more that another offensive tackle was taken before me, so I?m ready to go. . . .

?I?ll probably wake up every single day thinking that and when I?m in the weight room . . . when I?m lifting, when I?m out in the field working, you know, that?s my entire goal.? I grew up in a very competitive family, always wanted to be the best.? And you know, going behind another guy in my same position is definitely going to push me.?

It also puts pressure on Fisher.

?Obviously the first pick gets a lot of expectations, a lot of pressure, but I think I perform very well under pressure,? Fisher told PFT on Thursday night.? ?I am somebody to take advantage of pressure situations and make the most of them.? A lot of people will break under their pressure, I?m not that kind of person.? I think any time in my life I?ve had that kind of expectation that I needed to meet, I think I?ve performed very well.?

There?s a chance both will perform well.? There?s also a chance, in theory, of a Peyton Manning/Ryan Leaf dichotomy.

After spending time last night with each guy, our money?s on the former.

Source: http://profootballtalk.nbcsports.com/2013/04/26/packers-announce-aaron-rodgers-extension/related/

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Little Red Riding Hood by Nosy Crow for iPhone and iPad review: Help Little Red Riding Hood fight off the Big Bad Wolf

Nosy Crow has released an interactive story book of their version of the Little Red Riding Hood featuring fully-animated illustrations multiple paths that let you take control of the story.

Little Red Riding Hood by Nosy Crow is the same story we all know and love, but instead the gruesome part where the Huntsman rescues Grandma and Red by cutting them out of Wolf's stomach, Little Red Riding Hood collects items on her way to Grandma's house and uses them to fend off the Wolf herself. And Grandma is simply locked in a wardrobe, unharmed. Much more appropriate for children!

One of the great features of Little Red Riding Hood is that you get to have control over some of the story. Three different times, Red encounters a fork in the rode and much choose which direction to go. The choice you make for her determines what you end up helping her collect along the way.

In my version, Little Red Riding hood picked flowers that she used to make the Wolf sneeze, scooped water into a jar that she threw in the Wolf's face, and rescued a spider that ultimately scared the Wolf away.

The good

• Great graphics, animations, and artwork
• Very interactive
• Nine different games and activities embedded in the story
• Hundreds of interactive touch points
• Text highlighting to help young readers
• Universal for iPhone and iPad

The bad

• Not a fan of the little highlights that show you where to tap. I prefer kids discovering where to tap on their own.
• If you choose the spider path, you have to tilt the screen to help the spider through the web maze, but it doesn't work very well. After struggling for a bit, I was informed I could use my finger, so that's good.

The bottom line

I love this book. My daughter loves this book. If you have kids, Little Red Riding Hood by Nosy Crow is a keeper.

• $4.99 - Download now

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/1qwV5T21HbM/story01.htm

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Bold move forward in molecular analyses

Apr. 25, 2013 ? A dramatic leap forward in the ability of scientists to study the structural states of macromolecules such as proteins and nanoparticles in solution has been achieved by a pair of researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab). The researchers have developed a new set of metrics for analyzing data acquired via small angle scattering (SAS) experiments with X-rays (SAXS) or neutrons (SANS). Among other advantages, this will reduce the time required to collect data by up to 20 times.

"SAS is the only technique that provides a complete snapshot of the thermodynamic state of macromolecules in a single image," says Robert Rambo, a scientist with Berkeley Lab's Physical Biosciences Division, who developed the new SAS metrics along with John Tainer of Berkeley Lab's Life Sciences Division and the Scripps Research Institute.

"In the past, SAS analyses have focused on particles that were well-behaved in the sense that they assume discrete structural states," Rambo says. "But in biology, many proteins and protein complexes are not well-behaved, they can be highly flexible, creating diffuse structural states. Our new set of metrics fully extends SAS to all particle types, well-behaved and not well-behaved."

Rambo and Tainer describe their new SAS metrics in a paper titled "Accurate assessment of mass, models and resolution by small-angle scattering." The paper has been published in the journal Nature.

Says co-author Tainer, "The SAS metrics reported in our Nature paper should have game-changing impacts on accurate high-throughput and objective analyses of the flexible molecular machines that control cell biology."

In SAS imaging, beams of X-rays or neutrons sent through a sample produce tiny collisions between the X-rays or neutrons and nano- or subnano-sized particles within the sample. How these collisions scatter are unique for each particle and can be measured to determine the particle's shape and size. The analytic metrics developed by Rambo and Tainer are predicated on the discovery by Rambo of an SAS invariant, meaning its value does not change no matter how or where the measurement was performed. This invariant has been dubbed the "volume-of-correlation" and its value is derived from the scattered intensities of X-rays or neutrons that are specific to the structural states of particles, yet are independent of their concentrations and compositions.

"The volume-of-correlation can be used for following the shape changes of a protein or nanoparticle, or as a quality metric for seeing if the data collection was corrupted," Rambo says. "This SAS invariant applies equally well to compact and flexible particles, and utilizes the entire dataset, which makes it more reliable than traditional SAS analytics, which utilize less than 10-percent of the data."

The volume-of-correlation was shown to also define a ratio that determines the molecular mass of a particle. Accurate determination of molecular mass has been a major difficulty in SAS analysis because previous methods required an accurate particle concentration, the assumption of a compact near-spherical shape, or measurements on an absolute scale.

"Such requirements hinder both accuracy and throughput of mass estimates by SAS," Rambo says. "We've established a SAS-based statistic suitable for determining the molecular mass of proteins, nucleic acids or mixed complexes in solution without concentration or shape assumptions."

The combination of the volume-of-correlation with other metrics developed by Rambo and Tainer can provide error-free recovery of SAS data with a signal-to-noise ratio below background levels. This holds profound implications for high-throughput SAS data collection strategies not only for current synchrotron-based X-ray sources, such as Berkeley Lab's Advanced Light Source, but also for the next-generation light sources based on free-electron lasers that are now being designed.

"With our metrics, it should be possible to collect and analyze SAS data at the theoretical limit," Rambo says. "This means we can reduce data collection times so that a 90- minute exposure time used by commercial instruments could be cut to nine minutes."

Adds Tainer, "The discovery of the first x-ray scattering invariant coincided with the genesis of the Berkeley Lab some 75 years ago. This new discovery of the volume-of-correlation invariant unlocks doors for future analyses of flexible biological samples on the envisioned powerful next-generation light sources.

This research was funded through DOE's Office of Science and the National Institutes of Health.

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Story Source:

The above story is reprinted from materials provided by DOE/Lawrence Berkeley National Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Robert P. Rambo, John A. Tainer. Accurate assessment of mass, models and resolution by small-angle scattering. Nature, 2013; 496 (7446): 477 DOI: 10.1038/nature12070

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/physics/~3/qLdwcpMQTGs/130425132703.htm

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Five Favorite Films with Dennis Quaid

Dennis Quaid came into his own as one of the astronauts in 1983's The Right Stuff, and has since been one of America's hardest-working, most consistent actors, appearing in everything from Innerspace and Wyatt Earp to Far from Heaven and Traffic. (And lest we forget his gallant, if doomed, effort to hold together Movie 43.) This week he plays dad to Zac Efron's rebellious son in Ramin Bahrani's At Any Price, and with the film opening in limited release, we had a chance to sit down with Quaid recently and talk about his favorite movies.

I think my favorite movie is Lawrence of Arabia. To me, it's just about a perfect film; in the performances and what it means to me. I saw it as a boy -- and I just can't stop watching it, every time it comes on. All David Lean's movies, really. I love Doctor Zhivago, too.

Five Easy Pieces is a film that hit me as a young man. Most of my favorite movies, I think, come from the '70s, in that period where I really wanted to become an actor. Jack Nicholson's performance in that... it's a film that would never be done by a major studio today.

There's Bonnie and Clyde. That's a film that kind of started the new wave in the '70s. That was incredible. I saw that when I was in about the eighth grade, I think. Those characters, and also the history of Bonnie and Clyde, you know... it was something new. I remember, in fact, Bonnie and Clyde came out in either late Spring or early Summer, and then it was pulled. I think it flopped when it came out, and then they brought it back out in the Fall. I mean, I loved it when I first saw it; then they brought it back out in the Fall and it was a huge success.

Scarecrow (Jerry Schatzberg, 1973; 71% Tomatometer)

There's another movie back then called Scarecrow, with Gene Hackman and Al Pacino. They play two hobos that are going across America to open up a car wash. Both performances are just amazing.

I'm gonna say The Godfather -- the first one. That's another movie that's just about a perfect film, you know, from a great filmmaker in his prime.

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At Any Price opens in limited release this week.

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Source: http://www.rottentomatoes.com/m/1927319/news/1927319/

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Psychopaths are not neurally equipped to have concern for others

Apr. 24, 2013 ? Prisoners who are psychopaths lack the basic neurophysiological "hardwiring" that enables them to care for others, according to a new study by neuroscientists at the University of Chicago and the University of New Mexico.

"A marked lack of empathy is a hallmark characteristic of individuals with psychopathy," said the lead author of the study, Jean Decety, the Irving B. Harris Professor in Psychology and Psychiatry at UChicago. Psychopathy affects approximately 1 percent of the United States general population and 20 percent to 30 percent of the male and female U.S. prison population. Relative to non-psychopathic criminals, psychopaths are responsible for a disproportionate amount of repetitive crime and violence in society.

"This is the first time that neural processes associated with empathic processing have been directly examined in individuals with psychopathy, especially in response to the perception of other people in pain or distress," he added.

The results of the study, which could help clinical psychologists design better treatment programs for psychopaths, are published in the article, "Brain Responses to Empathy-Eliciting Scenarios Involving Pain in Incarcerated Individuals with Psychopathy," which appears online April 24 in the journal JAMA Psychiatry.

Joining Decety in the study were Laurie Skelly, a graduate student at UChicago; and Kent Kiehl, professor of psychology at the University of New Mexico.

For the study, the research team tested 80 prisoners between ages 18 and 50 at a correctional facility. The men volunteered for the test and were tested for levels of psychopathy using standard measures.

They were then studied with functional MRI technology, to determine their responses to a series of scenarios depicting people being intentionally hurt. They were also tested on their responses to seeing short videos of facial expressions showing pain.

The participants in the high psychopathy group exhibited significantly less activation in the ventromedial prefrontal cortex, lateral orbitofrontal cortex, amygdala and periaqueductal gray parts of the brain, but more activity in the striatum and the insula when compared to control participants, the study found.

The high response in the insula in psychopaths was an unexpected finding, as this region is critically involved in emotion and somatic resonance. Conversely, the diminished response in the ventromedial prefrontal cortex and amygdala is consistent with the affective neuroscience literature on psychopathy. This latter region is important for monitoring ongoing behavior, estimating consequences and incorporating emotional learning into moral decision-making, and plays a fundamental role in empathic concern and valuing the well-being of others.

"The neural response to distress of others such as pain is thought to reflect an aversive response in the observer that may act as a trigger to inhibit aggression or prompt motivation to help," the authors write in the paper.

"Hence, examining the neural response of individuals with psychopathy as they view others being harmed or expressing pain is an effective probe into the neural processes underlying affective and empathy deficits in psychopathy," the authors wrote.

The study with prisoners was supported with a $1.6 million grant from the National Institute of Mental Health.

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The above story is reprinted from materials provided by University of Chicago, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Jean Decety, Laurie R. Skelly, Kent A. Kiehl. Brain Response to Empathy-Eliciting Scenarios Involving Pain in Incarcerated Individuals With Psychopathy. JAMA Psychiatry, 2013 DOI: 10.1001/jamapsychiatry.2013.27

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/uRcT0SkoiG0/130424161108.htm

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Don't lecture: Inject some drama ? Business Management Daily ...

Before you address a roomful of employees, identify the main point you want to make. Then figure out a memorable way to convey that point.

Consider how Jack Welch, General Electric?s former CEO, informed his top managers of the kind of organizational culture he wanted to create. Instead of lecturing them, he injected some drama.

In 1992, GE had just completed a wildly successful year. Hosting a retreat for his senior executives, Welch surprised the group by beginning his speech with a blunt observation.

?Look around you,? he told the crowd. ?There are five fewer officers here than there were last year. One was fired for the numbers, four were fired for values.?

Instantly, he had everyone?s attention. He explained that he divided his direct reports into four categories:

• Type I are stars who fulfill their commitments and share GE's values.
• Type II don?t meet their commitments and don?t embody the values. He added that they don?t last long at GE.
• Type III put in the effort, share GE?s values but sometimes miss their commitments. They deserve another chance, Welch said.
• Type IV consistently deliver the numbers, but alienate others with their bullying behavior.

Welch said that he had started to fire Type IVs because he felt they compromised the culture, undermined teamwork and made life unpleasant for others.

His presentation hit home with his lieutenants. He conveyed a clear message by listing four easy-to-understand categories and emphasizing that certain behavior was no longer acceptable.

? Adapted from What Management Is, John Magretta and Nan Stone, Free Press.

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Americans Suffer While Finance Tax Waits for Congress' Attention ...

Americans Suffer While Finance Tax Waits for Congress? Attention

Posted on Apr?24,?2013

By Thomas Hedges, Center for Study of Responsive Law

More than a thousand people gathered in Washington, D.C.?s Farragut Square on Saturday to demand that a financial transaction tax be placed on derivatives and other forms of speculation. The proposed tax on financial transactions, detailed in a bill Rep. Keith Ellison, D-Minn., introduced to Congress a week ago, would generate more than $300 billion a year in revenue, thereby doing away with the need for the sequester currently forcing across-the-board budget cuts.

The Financial Transaction Tax, or Robin Hood Tax, has a broad base of support. Nurses, environmentalists, union workers, and people living with HIV/AIDS, for example, spoke at the rally on behalf of Americans who have been exploited at the expense of profit on Wall Street. The tax resonates with many Americans because of its simplicity and concrete purpose?it takes a modest percentage of profits from a multitrillion dollar market on Wall Street and uses that revenue to rebuild the crumbling infrastructure that allowed financial corporations to generate their wealth in the first place.

Transaction taxes aren?t new. The United States had one from 1914 to 1966. In 1932, it was more than doubled to 0.05 percent to help recovery after the Great Depression. Today, more than 40 countries have a transaction tax, with 11 in the European Union, including Germany and France.

After 1966, the tax was eliminated and replaced with a modest Financial Speculation Tax that now finances the Securities and Exchange Commission as well as the Commodities Futures Trading Commission, two agencies Wall Street emaciated in the following decades.

The transaction tax is also meant to rein in speculative trading and help prevent financial bubbles that in the last 15 years have become a chronic problem.

?It?s actually a good, old-fashioned economic solution,?? Jared Bernstein, former chief economist and economic adviser to Vice President Joe Biden, wrote in support of the tax. ?Internalize the negative externalities of bad risk pricing and volatility but making it more expensive to lurch. ... It would also raise some much needed revenue which, if I?m right, we?re going to need the next time the herd runs off the cliff ... together.?

Sixty percent of Americans support a transaction tax, including such people as Warren Buffett, Eliot Spitzer, Larry Summers and the members of The Boston Globe editorial board.

?As Obama and other policymakers contemplate far-reaching changes to entitlements such as Medicare and Social Security,? The Boston Globe editorialized in 2011, ?a financial transaction tax?which would simultaneously raise money and deter another crisis?has to be part of the discussion.?

Although we do not yet have a financial transaction tax, President Obama is moving forward with cuts to social programs, public services, Medicare/Medicaid and Social Security.

At the rally Saturday, speakers said that cuts to any sector of the economy were an assault on the general public.

?We?re losing transit as a result of what?s happened to our economy, as a result of the fact that our government has seen fit to bail out banks but not people,? Amalgamated Transit Union President Larry Hanley explained to the crowd of protesters wearing Robin Hood hats. ?Let me tell you, there?s something perverse in a nation that sees fit to slash transit services to people who need it, at a time when people are losing their jobs and have fewer cars.

?When I was growing up,? he continued, ?when I was in school, they talked about citizenship because we were citizens. But somewhere along the line they turned us into consumers and then taxpayers, as if the only role we serve in life is to be angry taxpayers, angry at everybody else who is struggling in this country.?

A growing private sector and shrinking public one does not bode well for people who have little economic value. Those who depend on food stamps, affordable housing, Medicaid, Medicare and other forms of government assistance are the first to feel that shift?s pinch.

In the most recent study on poverty-related deaths, researchers at Columbia University?s Mailman School of Public Health found that 875,000 people died in the U.S. as a result of social factors such as poverty and income inequality in 2000, when income disparity was much smaller than it is today.

?People living with HIV and AIDS depend on medication to live,? activist Jose Demarco told the demonstrators, speaking on behalf of the sick who cannot afford patented drugs. ?Our fate is miserable, slow, painful deaths. This year the budget did not include money for AIDS drugs. What are we supposed to do? Die.?

This article was made possible by the Center for Study of Responsive Law.

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Source: http://www.truthdig.com/report/item/americans_suffer_while_finance_tax_waits_for_congress_attention_20130424/

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Rocket Internet-Backed Fashion Portal Zalora Launches iOS App, No Word Of Android Yet

Zalora, Rocket Internet's pan-Asian fashion retail site, has launched an iOS app, as it seeks to capture the growing base of consumers in Asia who are using smartphones as their primary, and sometimes only, way of getting online.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/c-Fmj7Iewq0/

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NFL group, company teaming up for brain drug test

NEW YORK (AP) ? A potential treatment for traumatic brain injuries may be tested in retired professional football players, who are the focus of concern over blows to the head.

Neuralstem, Inc., of Rockville, Md., said Wednesday it is working with the National Football League Alumni Association to study the feasibility of such a test, which would need government approval. It would involve a drug that's now in an early human trial for treating depression. In animal studies, the drug appeared to stimulate creation of brain cells.

Concern has mounted about brain injuries and disease in former NFL players, driven in part by some high-profile suicides. Thousands of former players are suing the league and its teams, saying that for years the NFL did not do enough to protect players from concussions.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-04-24-NFL-Brain%20Injury/id-322ea11de6264f5f806bd35c94be7a30

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Top 10 Bizarre Arthropods | ManmadeMag - Jennings Boyce 42's blog

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Mont. man reunited with bird he lost in a divorce

BUTTE, Mont. (AP) ? A Great Falls man who lost his macaw in a divorce about five years ago has been reunited with the bird, thanks to an observant friend.

Mike Taylor picked up the bird he calls "Love Love" at Montana's Parrot & Exotic Bird Sanctuary in Butte on Sunday.

After a friend of his earlier spotted the bird there, Taylor called sanctuary founder Lori McAlexander and said it was his. Taylor knew things about the bird that only he could have known ? like it was blind in one eye and said "love love."

McAlexander says the bird was surrendered after it bit a woman so hard she required medical attention.

Taylor says he initially got the bird after it was rescued from a woman who reportedly beat it with a broom.

Source: http://news.yahoo.com/mont-man-reunited-bird-lost-divorce-153513517.html

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Why I?m not happy & gay about immigration reform (Americablog)

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How a Quaker missionary from Philly became India's Johnny Appleseed

Samuel Evans Stokes?spent years trying to persuade his neighbors in the Himalayas to grow apples, giving away plants freely until?locals took to apple farming and Indians took to Red Delicious.

By Vaishnavi Chandrashekhar,?Correspondent / April 22, 2013

A community hall in rural India is not the place you would expect to find a garlanded portrait or statue of a Quaker missionary from Philadelphia. But both those things can be found at the farmers? hall in Thanedar, the ?apple bowl? of the Himalayan state of Himachal Pradesh in India.

Skip to next paragraph Vaishnavi Chandrashekhar

India Correspondent

Vaishnavi Chandrashekhar is a freelance journalist based in Mumbai, India. She previously worked with?The Christian Science Monitor?as a staff editor on the national news desk in Boston from 2008-2010. She has also worked for?The Times of India?in Mumbai and?Time Out Mumbai.?She has a master's in journalism from Columbia University.?

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Every farmer here can ? and will ? tell you about Samuel Evans Stokes, or Satyanand Stokes as he came to be known. He was an American missionary who settled in this area in the early 20^th century, participated in India?s struggle for independence as a co-traveller of Mahatma Gandhi, and became the Johnny Appleseed of the northwestern Himalayas.

Stokes seeded a horticultural revolution when he planted five saplings of Red Delicious ? bought from the Starks Brothers nursery in Louisiana ? on his farm here in 1916, and helped convert locals to apple farming.

Stokes?s extraordinary journey began in turn-of-the-19^th -century Philadelphia where, at a church meeting, he heard an American doctor talk about working with lepers in India. Inspired, this son of a wealthy Quaker family (the founders of the elevator manufacturers, Stokes and Parish Machine Company) gave up his post-graduate studies at Cornell University and joined the doctor on a steamship to Bombay in 1904.

For a time, according to family accounts, Stokes worked at the doctor?s home for lepers in the plains. He fell ill and was sent to recuperate in the hills near Shimla, then the summer capital of the British Raj, at a cantonment village called Kotgarh.

Smitten by Kotgarh ? which Rudyard Kipling called ?mistress of the hills? ? Stokes stayed on. He experimented with renunciation, living in a cave like an Indian sadhu, and founded the Brotherhood of Imitation of Jesus, traveling from village to village preaching. A few years later, he married an Indian woman, bought a former tea estate in Thanedar, and focused on farming. ?In 1914, he took local soil samples to America, returning with Red Delicious stocks.

Stokes spent years trying to persuade his neighbors to grow apples, giving away plants freely, says Vidya Stokes, who married Samuel Stokes?s son, Lal Chand, and is the current horticulture minister of Himachal Pradesh.

Initially, few farmers listened, she said. They knew only the cooking apples the British had brought ? Granny Smith and Pippin varieties that were too sour for Indian tastes.?

Stokes taught the boys in the school he established how to graft the plants, says Vidya Stokes. ?Their parents were skeptical, so the boys planted the saplings on the borders of their family farms,? she says.

When the first crops of Red Delicious came, however, ?everyone came to see,? she says. ?The apples were sweet. People realized they could make money from this.?

And they did ? Himachal?s apple orchards are valued today at around $550 million and provide a livelihood to more than 100,000 farmers.

Farming wasn?t the only way in which Samuel Stokes sought to help society, however. A believer in racial equality and social justice, he campaigned successfully to end a colonial system of forced labor in the hills and joined the Indian freedom struggle: signing petitions, engaging in debates on strategy with Gandhi and other nationalists, and adopting Indian clothes.

In 1921, he was the only non-Indian to be invited by Gandhi to sign a nationalist manifesto calling on Indians to quit government service ? he signed ? and was imprisoned for six months on charges of sedition.

In his later years, Samuel Stokes became more contemplative. In 1932, he and his family converted to Hindusim and changed his name to Satyanand. The temple he built ? without idols ? as well as Stokes?s home can still be seen today on his 200-acre estate in Thanedar. Most of Stokes descendants now live in America. ?

Stokes?s portrait also hangs in the Nehru Memorial Museum and Library in New Delhi, alongside pictures of Mahatma Gandhi and other leaders of the Indian independence movement.

But it?s the farmers of Himachal Pradesh who remember him ? as the man who transformed the region and their lives ? with apples from America.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/ux00U-T55_Y/How-a-Quaker-missionary-from-Philly-became-India-s-Johnny-Appleseed

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Gillmor Gang Live 04.20.13 | TechCrunch

Gillmor Gang ? Robert Scoble, Kevin Marks, John Taschek, and Steve Gillmor. Recording for today has concluded. Check Techcrunch soon for replay.

Robert Scoble is an American blogger, technical evangelist, and author. He is best known for his popular blog, Scobleizer, which came to prominence during his tenure as a technical evangelist at Microsoft. Scoble joined Microsoft in 2003, and although he often promoted Microsoft products like Tablet PCs and Windows Vista, he also frequently criticized his own employer and praised its competitors like Apple and Google. Scoble is the author of Naked Conversations, a book on how blogs are changing...

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Kevin Marks is a software engineer. Kevin served as an evangelist for OpenSocial and as a software engineer at Google. In June 2009 he announced his resignation. From September 2003 to January 2007 he was Principal Engineer at Technorati responsible for the spiders that make sense of the web and track millions of blogs daily. He has been inventing and innovating for over 17 years in emerging technologies where people, media and computers meet. Before joining Technorati,...

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John Taschek is vice president of strategy at salesforce.com. He is responsible for corporate product strategy, corporate intelligence and market influence. Taschek came to company in 2003, bringing over 20 years of technology evaluation experience. Taschek currently is also the editorial director for CloudBlog - an independent blog run as an adjunct to salesforce.com?s web properties. He occasionally is on Steve Gillmor?s The Gillmor Gang enterprise web video-cast. Previously, Taschek ran the testing labs at eWEEK (formerly PC Week) magazine....

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Steve Gillmor is a technology commentator, editor, and producer in the enterprise technology space. He is Head of Technical Media Strategy at salesforce.com and a TechCrunch contributing editor. Gillmor previously worked with leading musical artists including Paul Butterfield, David Sanborn, and members of The Band after an early career as a record producer and filmmaker with Columbia Records? Firesign Theatre. As personal computers emerged in video and music production tools, Gillmor started contributing to various publications, most notably Byte Magazine,...

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Source: http://techcrunch.com/2013/04/20/gillmor-gang-live-04-20-13/

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Yoga Can Help Polycystic ovary syndrome (PCOS) | Healthy Living ...

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Polycystic ovary syndrome (PCOS) is a common occurrence today in women at a reproductive age. At least 5 to 10% of the young women (as suggested by the National Institutes of Health research) are diagnosed with this condition. And many have started acknowledging the role of yoga as a safe treatment option.

As Dr.Pratima Malik, Gynaecologist, Apollo Hospitals, states, ?The highly ambitious, stressed-out working woman of today is likely to be more prone to Polycystic ovary syndrome?.
?
How to find out if you have Polycystic ovary syndrome?

???? Irregular or no menstrual cycles at all
???? Frequent hair loss and heavy hair growth on the face, back, stomach, arms and legs
???? Heavy acne
???? Frequent mood swings
???? Weight gain
???? Infertility

?Although it is impossible to eliminate stress completely from our day-to-day life, we can surely build up our capacity to deal with it. This is where yoga and meditation help.

What role does yoga play in PCOS?

The science of yoga works at levels much more subtler and deeper than just the physical body level. Yoga helps release deeply stored stress in the system, which can help improve PCOS symptoms.

Asanas (yoga postures) designed for PCOS help open up the pelvic area and promote relaxation and pranayamas (breathing exercises) are powerful techniques that help calm the mind. Coupled with these are some soothing meditations that work at a very deep level and help de-toxify and de-stress the entire system.

Yoga Exercises to Improve PCOS:

Butterfly Pose can be very helpful in PCOS. Don?t flap your legs too much; instead try holding the posture for long.

Even more helpful is SuptaBadhakonasana (Reclining Butterfly Pose), which works just like the Butterfly Pose, this time lying down. This is what makes it extremely relaxing. To enhance the experience, play some soft music and place cushions under your hip. For beginners, it is a good idea to use cushion support while doing this posture.

Bharadvajasana (Bharadvaja?s Twist) is a seated spinal twist that helps PCOS patients.

Chakki Chalanasana (moving the grinding wheel) is a very simple exercise with several benefits. It helps massage the liver, kidneys, pancreas, uterus and the reproductive organs.

Shavasana (Corpse Pose) is another useful posture to try. In PCOS, the more you relax, the better you feel and this posture will help you completely relax at the end of your yoga session.

Padma Sadhana practice is also considered very effective for PCOS patients.

*Inputs :Dr. Sejal Shah, Sri Sri Yoga teacher, The Art of living, www.artofliving.org/yoga

*Images courtesy: ? Thinkstock photos/ Getty Images

Source: http://healthmeup.com/news-healthy-living/yoga-can-help-polycystic-ovary-syndrome-pcos/19899

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Will the GOP Embrace Amnesty?

Click if you like this column!

During President Eisenhower's first term, 60 years ago, the United States faced an invasion across its southern border.

Illegal aliens had been coming since World War II. But, suddenly, the number was over 1 million. Crime was rising in Texas. The illegals were taking the jobs of U.S. farm workers.

Under Gen. Joseph May Swing, the Immigration and Naturalization Service launched "Operation Wetback" and began rounding up and deporting Mexican border-crossers by ship and bus. By the end of Ike's second term, illegal entries had fallen by 90 percent.

Eisenhower, who had tapped his nuclear hole card twice -- first, to force the Chinese to agree to a truce in Korea, then to halt their shelling of the offshore islands in 1958 -- was a no-nonsense president.

Measured by population and gross national product, Eisenhower's America was but half the size of today's America. Yet, in the 1950s, we were in many ways a stronger and more self-confident country.

We had universal military service, and few complained. As for the deportation of the Mexicans, they had broken in, they did not belong here, and they were going back. End of discussion.

Contrast the rigorous response of Ike's America to an invasion across our southern border to the hand-wringing moral paralysis of our political elite in dealing with 11-12 million illegal aliens in our midst.

We are to stop using terms like illegal aliens, we are told. For it shows insensitivity. And compassion commands that we bring these folks "out of the shadows" and "put them on a path to citizenship."

One understands Democrats' motives in pushing this amnesty. Perhaps nine of 10 illegals are from Third World countries, and folks of Asian, African and Hispanic descent voted 4-to-1 Democratic in 2012.

Sen. Chuck Schumer and Democrats are writing an immigration bill that will create millions of new citizens who will vote to bury the Party of Ronald Reagan forever.

But why are Republicans collaborating in erecting the scaffolding on which their party is to be hanged?

A year ago, the GOP platform declared, "We oppose amnesty because it would have the effect of encouraging illegal immigration and would give an unfair advantage to those who have broken our laws."

What has changed since then?

Yet, today, with Cuban-American Sen. Marco Rubio providing cover -- a "very positive force," purrs President Obama -- Republicans are about to trash their platform and vote an amnesty for 11-12 million illegals. Why?

Source: http://townhall.com/columnists/patbuchanan/2013/04/19/will-the-gop-embrace-amnesty-n1572261

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Venezuela crackdown called worst in years

CARACAS, Venezuela (AP) ? National Guard troops beat dozens of opposition supporters inside a barracks for refusing to accept the government-certified electoral victory of Hugo Chavez's heir, a leading human rights lawyer charged Thursday in what he called Venezuela's worst political repression in six years.

Alfredo Romero said his group's lawyers also compiled evidence supporting opposition activists' claims that National Guard troops had used excessive force against protesters, including shooting some point-blank with plastic shotgun pellets.

As details of the crackdown emerged, Nicolas Maduro prepared to be sworn in as president and the speaker of the National Assembly again threatened to bar the opposition from its only remaining political platform, the legislature, unless it recognized Maduro's legitimacy.

Romero said the beatings occurred at National Guard barracks No. 47 in the western city of Barquisimeto after at least 300 protesters were arrested across Venezuela for backing opposition candidate Henrique Capriles' demand for a recount of all the votes cast Sunday.

Interrogators "put baseball caps on these kids' heads with a pro-government insignia ... and made them say they recognized the Maduro government, and if they said 'No' they were beaten," Romero said, adding that most of the detainees ranged in age from 15 to 22.

Asked about the allegations, Interior Ministry spokesman Jorge Galindo called them "totally false, absurd and without basis." He said the detainees, though in a military barracks, were being overseen by ministry officials to "guarantee their rights."

Romero called the crackdown Venezuela's worst since Chavez shut down the opposition TV station RCTV in 2006 when more than 250 people were arrested. His 12-year-old group, Foro Penal Venezolano, has more than 200 lawyers who represent without charge people they consider political prisoners.

He said the group has complained to the Inter-American Human Rights Commission, whose rulings Venezuela's government no longer recognizes, and is preparing a complaint to the International Criminal Court.

One of the worst cases of excessive force this week occurred in the central city of Valencia, members of the opposition's youth wing said in Caracas.

They said National Guardsmen fired plastic pellets at extremely close range at a group protesting the regime-friendly National Electoral Council's decision to ratify the victory of Nicolas Maduro.

Maduro is to be sworn in Friday in the National Assembly at a ceremony being boycotted by the opposition because its deputies are not being allowed to address the body unless they recognize his presidency as legitimate.

The government says 15 countries including Iran, China and Saudi Arabia were sending high-level delegations. Brazil said its president, Dilma Rousseff, was attending as was Argentina's Cristina Fernandez, but it was not clear whether the president of neighboring Colombia, Juan Manuel Santos, would attend.

On Thursday, Maduro headed to Lima, Peru, for an evening meeting of presidents of the Union of South American Nations, UNASUR, to discuss Venezuela's post-election tensions.

The meeting was convened by Peru's president, Ollanta Humala, who holds the organization's rotating chair, and every leader on the continent save Ecuador's Rafael Correa, who was traveling in Europe, was attending, said Peru's deputy foreign minister, Fernando Rojas.

The youth opposition wing members displayed photographs showing deep, bloody wounds on the skin the hand and arm of Jonny Alvarado, a local leader of the centrist Proyecto Venezuela party who they said had been shot three times in the arm and undergone two surgeries in an attempt to save his hand.

The AP confirmed Alvarado's non-life-threatening injuries with the director of the hospital where he was treated.

At least 10 other activists were hit by pellets, some in the head, but not hurt as seriously, said Carlos Graffe, Proyecto Venezuela's youth leader. He said other protesters were punched or hit with batons by National Guardsmen.

A total of 400 were injured nationwide by authorities and government backers, said Juan Requesens, national coordinator of the opposition's youth wing.

In Monagas state, a group of 30 to 40 protesters was attacked by pro-government forces, then detained by authorities when they tried to flee, said Diego Scharifker, president of the youth wing of the Nuevo Tiempo party. He said virtually all were anti-government, but National Guard members had even swept up a handful of pro-government youth during sweeps of streets.

Romero said other activists described being arrested as they were walking home from peaceful protests.

The government alleges Capriles' backers have incited all the postelection violence, which it says has caused eight deaths and 70 injuries. It also charges the opposition loyalists have burned eight health clinics and several offices of the ruling United Socialist Party of Venezuela.

Non-government media and private citizens have published photos of unmolested clinics and party offices that they said disproved the claims.

Chief Prosecutor Luisa Ortega reiterated on Thursday the government's contention that neither it nor its supporters were to blame for any of the violence that followed Sunday's vote.

"A common denominator is that the wounded and injured are all supporters of Chavismo," she said in an interview on state TV.

Romero said 71 youths in all were arrested in Barquisimeto on Monday and Tuesday, when opposition supporters marched on regional offices of the electoral council, while 83 were arrested in Valencia over those two days.

He said it appeared that most were being freed Thursday, but that many faced criminal charges that include public incitement, destroying public property and other crimes.

Other arrests occurred in the states of Barinas, Merida and Maracay, Romero added, but he said he didn't have solid information on events there.

The prosecutor, Ortega, said Thursday that a total of 135 people had been arrested across Venezuela, with 90 of them charged with crimes.

The country awaited, meanwhile, word on whether the electoral council would agree to Capriles demand for a vote-by-vote recount after receiving the opposition's petition on Wednesday.

National Assembly Speaker Diosdado Cabello repeated the threat he made Tuesday to bar the opposition from the chamber, it's only platform on the national political stage. The opposition has just three of Venezuela's 23 governorships.

"I repeat to deputies of the opposition, just in case by chance they didn't understand, if they don't recognize Maduro as president I won't recognize them in the AN (National Assembly)."

There would be no constitutional basis for such an action, but Maduro and his ruling circle has paid little heed to the document since their mentor disappeared in December to Cuba for cancer surgery, never to be heard from publicly again.

Cabello was one of the closest allies of Chavez, who died March 5 after a long battle with cancer.

The ruling socialists control the legislature with 165 seats to 98 for the opposition and elections are not due until next year.

___

Associated Press writers E. Eduardo Castillo and Vivian Sequera contributed to this report.

___

Frank Bajak on Twitter: http://twitter.com/fbajak

Michael Weissenstein on Twitter: http://twitter/mweissenstein

Source: http://news.yahoo.com/venezuela-crackdown-deemed-worst-years-230149996.html

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Bryce Harper is mad about a game-worn jersey selling at auction ...

Washington Nationals superstar Bryce Harper had a brilliant game against the Miami Marlins on April 1 to open up his 2013 regular season campaign. He tore the cover off the ball, going 2-4, with the two hits both being home runs, jump-starting a season that by all appearances will be a phenomenal one for the second-year outfielder.

The jersey that Harper was wearing that particular game, apparently unbeknownst to him, was recently sold through the auction arm of MLB.com. And Harper is none too pleased about how a prized memento was just taken away from him and sold for?

Over 13,000 smackeroos? Wow. That?s a lot of Chipotle burritos. Not that Harper needs the money for those.

Harper took to Twitter on Thursday to express his dismay over the pilfering of his game-worn jersey by the Nationals and/or Major League Baseball.

Via @Bharper3407:

Harper continues, addressing how any of the proceeds from the sale of the jersey better have gone to charity or some worthy cause and not lining the pockets of the Nationals or MLB:

Much to Harper?s relief I am sure, D.C. Sports Bog reports that the MLB auction does in fact indicate that all proceeds do go to charity. Nevertheless, Harper is without a keepsake from his memorable game. A person might ask: Will he get over it? Of course he will. That?s a clown question. Bro.

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Avis aux m?dias : Le gouverneur g?n?ral organisera une discussion sur les partenariats en ?ducation entre le Canada et l'Afrique

18 avr. 2013 10h00 HE

OTTAWA, ONTARIO--(Marketwired - 18 avril 2013) - Son Excellence le tr?s honorable David Johnston, gouverneur g?n?ral du Canada, organisera une discussion en table ronde sur les partenariats en ?ducation entre le Canada et l'Afrique le 22 avril 2013, de 10 h ? midi, ? Rideau Hall.

Le gouverneur g?n?ral sera accompagn? de M^me Reeta Roy, pr?sidente et premi?re dirigeante de la MasterCard Foundation; de M. David Naylor, pr?sident de l'Universit? de Toronto; de M. Stephen Toope, pr?sident et vice-chancelier de l'Universit? de la Colombie-Britannique et pr?sident de l'Association des universit? et coll?ges du Canada; et de M^me Heather Munroe-Blum, principale et vice-chanceli?re de l'Universit? McGill. ? cette occasion, son Excellence prononcera le discours d'ouverture et le mot de la fin.

Les quatre experts suivants participeront ? la discussion, qui sera anim?e par M. Paul Wells, r?dacteur politique au magazine Maclean's :

• M. Gerald Bareebe, boursier Sauv? et journaliste ougandais;
• M^me Antoinette Handley, professeure agr?g?e, D?partement des sciences politiques, Universit? de Toronto;
• M. James Mwangi, chef de la direction g?n?rale et administrateur d?l?gu?, Equity Bank;
• M. Stephen Toope, pr?sident et vice-chancelier, Universit? de la Colombie-Britannique et pr?sident de l'Association des universit?s et coll?ges du Canada.

Ensemble, ils discuteront du concept de la ? diplomatie du savoir ? d?fini par Son Excellence et de la mani?re dont les ?tablissements d'enseignement postsecondaire peuvent faciliter l'apprentissage entre les nations et l'?mergence de citoyens du monde. Les participants ? la table ronde examineront ?galement les fa?ons dont le Canada et l'Afrique pourraient promouvoir les partenariats en ?ducation, notamment par l'entremise du Scholars Program de la MasterCard Foundation. Pour en savoir davantage sur ce programme, visitez www.mastercardfdnscholars.org (en anglais seulement).

Les repr?sentants des m?dias qui souhaitent couvrir cet ?v?nement sont pri?s de confirmer leur pr?sence aupr?s du Bureau de presse de Rideau Hall et de se pr?senter ? l'entr?e Princesse Anne avant 9 h 45 le jour de l'?v?nement.

Suivez GGDavidJohnston et RideauHall sur Facebook et Twitter.

Source: http://www.marketwire.com/mw/release.do?id=1780347&sourceType=3

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Anti-sickling therapies should be focus for sickle cell science

Public release date: 17-Apr-2013
[ | E-mail | Share ]

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

AUGUSTA, Ga. Pain is an undeniable focal point for patients with sickle cell disease but it's not the best focus for drug development, says one of the dying breed of physicians specializing in the condition.

Rather scientists need to get back to the crux of the disease affecting 1 in 500 black Americans and find better ways to prevent the hallmark sickling that impedes red blood cells' oxygen delivery, damaging blood vessel walls and organs along the way, said Dr. Abdullah Kutlar, Director of the Sickle Cell Center at the Medical College of Georgia at Georgia Regents University.

"We have one drug that reduces sickling and we need more," said Kutlar, the 2013 Roland B. Scott, M.D., Lecturer for the 7th Annual Sickle Cell Disease Research and Educational Symposium and National Sickle Cell Disease Scientific Meeting April 14-17 in Miami.

"Pain is very important to someone who is suffering, but by using pain as an end point, we are missing opportunities and wasting drugs that could be very helpful," he said. "Moving forward, I suggest we develop new combination therapies that have anti-sickling capabilities at their center," said Kutlar, noting such cocktail approaches have worked well for cancer and HIV.

Kutlar completed an extensive historical review of patient and study outcomes in preparation for the lecture honoring the late Howard University physician who made it his mission to improve the lives of children with sickle cell disease. Scott's contributions include prompting the National Sickle Cell Control Act of 1972, which established the first federally-funded comprehensive sickle cell centers, including the one at MCG led by Dr. Titus H.J. Huisman.

No doubt Scott, Huisman and others have made a tremendous difference to patients, whose average life expectancy has gone from the teens to the 50s in the past 30 years, Kutlar said. Much of that progress grew out of focusing on the basics, including developing hydroxyurea, still the only Food and Drug Administration-approved drug that targets sickling.

Approved 15 years ago, hydroxyurea works by increasing expression of fetal hemoglobin, which can't sickle. However, it's still not widely used about 35 percent of Kutlar's adult patients take it, for example probably for a combination of reasons that include a side effect of weight gain and unsubstantiated concerns that it increases cancer risk. He and his colleagues need to do a better job communicating the benefits of this drug in addition to finding new ones, Kutlar said. Reduced sickling means less damage to blood vessels and organs, he said, noting that the major cause of death in adults and children is acute chest syndrome, a severe pneumonia resulting from cumulative lung damage. A handful of new anti-sickling drugs are in various stages of development, including a thalidomide- derivative pioneered by MCG researchers that also enhances fetal hemoglobin expression.

Other good endpoints for drug development include downstream effects of sickling, such as the unnatural adhesion of red blood cells to blood vessel walls, Kutlar said. Unfortunately work was recently halted on a drug that reduced adhesion but not pain, Kutlar said.

Pain needs to be the primary endpoint only for pain medications, he noted. The good news is that many new pain medications are available for these patients, whose pain crises can be severe enough to require hospitalization and whose chronic pain can impair daily living. However, that circles back to the complex causes of pain. The pain initially likely results from tissues crying out for more oxygen and later from nerve and organ damage resulting from ongoing impaired oxygen supplies. Pain control can get even more complex and difficult because regular use of opiates, a common analgesic for sickle cell patients, actually increases pain sensitivity, Kutlar said.

In addition to finding better therapies, physicians who treat sickle cell patients need to help cultivate the next generation of caregivers, Kutlar said. He's in the minority in that he opted to take care of patients with sickle cell disease rather than pursue the more common and generally more professionally lucrative hematology path: treating cancer. "We don't have enough hematologists, period," said Kutlar. The problem does have a good cause: the reality that more patients are living longer. However, the number of physicians to treat adult patients is dismal. Helping cultivate the next generation is a focus of a study led by Kutlar and Dr. Robert W. Gibson, a GRU occupational therapist and medical anthropologist. They are reaching out to primary care physicians who also are in short supply in this country as a permanent medical home for patients as they reach adulthood. Kutlar and Gibson are co-principal investigators on $7 million, five-year grant from the National Center on Minority Health and Health Disparities of the National Institutes of Health supporting this initiative as well as the search for new drugs and more.

MCG physicians follow about 1,500 adults and children with sickle cell disease.

###

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 17-Apr-2013
[ | E-mail | Share ]

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

AUGUSTA, Ga. Pain is an undeniable focal point for patients with sickle cell disease but it's not the best focus for drug development, says one of the dying breed of physicians specializing in the condition.

Rather scientists need to get back to the crux of the disease affecting 1 in 500 black Americans and find better ways to prevent the hallmark sickling that impedes red blood cells' oxygen delivery, damaging blood vessel walls and organs along the way, said Dr. Abdullah Kutlar, Director of the Sickle Cell Center at the Medical College of Georgia at Georgia Regents University.

"We have one drug that reduces sickling and we need more," said Kutlar, the 2013 Roland B. Scott, M.D., Lecturer for the 7th Annual Sickle Cell Disease Research and Educational Symposium and National Sickle Cell Disease Scientific Meeting April 14-17 in Miami.

"Pain is very important to someone who is suffering, but by using pain as an end point, we are missing opportunities and wasting drugs that could be very helpful," he said. "Moving forward, I suggest we develop new combination therapies that have anti-sickling capabilities at their center," said Kutlar, noting such cocktail approaches have worked well for cancer and HIV.

Kutlar completed an extensive historical review of patient and study outcomes in preparation for the lecture honoring the late Howard University physician who made it his mission to improve the lives of children with sickle cell disease. Scott's contributions include prompting the National Sickle Cell Control Act of 1972, which established the first federally-funded comprehensive sickle cell centers, including the one at MCG led by Dr. Titus H.J. Huisman.

No doubt Scott, Huisman and others have made a tremendous difference to patients, whose average life expectancy has gone from the teens to the 50s in the past 30 years, Kutlar said. Much of that progress grew out of focusing on the basics, including developing hydroxyurea, still the only Food and Drug Administration-approved drug that targets sickling.

Approved 15 years ago, hydroxyurea works by increasing expression of fetal hemoglobin, which can't sickle. However, it's still not widely used about 35 percent of Kutlar's adult patients take it, for example probably for a combination of reasons that include a side effect of weight gain and unsubstantiated concerns that it increases cancer risk. He and his colleagues need to do a better job communicating the benefits of this drug in addition to finding new ones, Kutlar said. Reduced sickling means less damage to blood vessels and organs, he said, noting that the major cause of death in adults and children is acute chest syndrome, a severe pneumonia resulting from cumulative lung damage. A handful of new anti-sickling drugs are in various stages of development, including a thalidomide- derivative pioneered by MCG researchers that also enhances fetal hemoglobin expression.

Other good endpoints for drug development include downstream effects of sickling, such as the unnatural adhesion of red blood cells to blood vessel walls, Kutlar said. Unfortunately work was recently halted on a drug that reduced adhesion but not pain, Kutlar said.

Pain needs to be the primary endpoint only for pain medications, he noted. The good news is that many new pain medications are available for these patients, whose pain crises can be severe enough to require hospitalization and whose chronic pain can impair daily living. However, that circles back to the complex causes of pain. The pain initially likely results from tissues crying out for more oxygen and later from nerve and organ damage resulting from ongoing impaired oxygen supplies. Pain control can get even more complex and difficult because regular use of opiates, a common analgesic for sickle cell patients, actually increases pain sensitivity, Kutlar said.

In addition to finding better therapies, physicians who treat sickle cell patients need to help cultivate the next generation of caregivers, Kutlar said. He's in the minority in that he opted to take care of patients with sickle cell disease rather than pursue the more common and generally more professionally lucrative hematology path: treating cancer. "We don't have enough hematologists, period," said Kutlar. The problem does have a good cause: the reality that more patients are living longer. However, the number of physicians to treat adult patients is dismal. Helping cultivate the next generation is a focus of a study led by Kutlar and Dr. Robert W. Gibson, a GRU occupational therapist and medical anthropologist. They are reaching out to primary care physicians who also are in short supply in this country as a permanent medical home for patients as they reach adulthood. Kutlar and Gibson are co-principal investigators on $7 million, five-year grant from the National Center on Minority Health and Health Disparities of the National Institutes of Health supporting this initiative as well as the search for new drugs and more.

MCG physicians follow about 1,500 adults and children with sickle cell disease.

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Source: http://www.eurekalert.org/pub_releases/2013-04/mcog-ats041713.php

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